Research on Cognitive Decline and Alzheimer’s

This post presents  the results of research into the possibilities of delaying or reversing the onset of cognitive decline that often leads onto Alzheimer’s and other dementia conditions.

Research on cognitive decline and Alzheimers update,191013 By Peter Senior, 13 October 2019

Hypothesis: the standard medical view that cognitive decline and Alzheimers can at best be partly alleviated and that there is no way to reverse it is false.

Objective: test this hypothesis.

This initial working paper comprises a draft chronological list of findings that appear to be of interest and relevance. Analysis and conclusions will follow shortly.

Click on link above to view the initial working paper. Further updates will be provided shortly.

The first item in the initial working paper describes the research carried out by Dr Dale Bredesen, together with a list of his protocal tests and a 58 minute video in which he explains his approach and protocol.

If you have any comments that will enhance this initial research before any conclusions are formed, please email them to

Index of contents:

  • Page 2 – Dr Dale Bredesen: End of Alzheimer’s. Description of book, protocol and articles
  • Page 10 – Summary of key tests for ReCode Protocol
  • Page 14 – Adam MacDougall, (summary of Dr Bredesen’s work)
  • Page 16 – The Buck Institute for Research on Aging
  • Page 16 – MoCA brain test
  • Page 16 – Brian exercises
  • Page 16 – Souvenaid
  • Page 16 – MCT oil 
  • Page 16 – Ashwagandha, an Indian herb
  • Page 16 – The APOE gene 
  • Page 16 – Redimind mixture / tonic (Nutreance)
  • Page 17 – Mayo Clinic
  • Page 17 –
  • Page 17 – National Institute of Aging
  • Page 17 –
  • Page 18 – Alzheimer’s Natural Treatment Options, Dr Josh Axe
  • Page 19 – New Scientist article
  • Page 20 – UK National Health
  • Page 20 – UCLA research May 2017
  • Page 21 – Natural News article
  • Page 22 – article
  • Page 22 – (2 articles)
  • Page 23 – Harvard Medical School
  • Page 24 – NCBI National Centre for Biological Information
  • Page 25 – Medical News Today – article
  • Page 25 – TED video
  • Page 25 – Dietician Amylee Amos
  • Page 25 – 7th BioCeuticals Research Symposium, May 2019
  • Page 26 – YouTube TED talk, Oct 17, 2015: Alzheimer’s Is Not Normal Aging — And We Can Cure It
  • Page 27 – Collective Evolution, 2018 article
  • Page 28 – The NeuroDevelopment Center, Providence, Rhone Island, USA
  • Page 29 – Life Extension
  • Page 32 – Alzheimers Association
  • Page 33 – UC Berkeley School of Public Health
  • Page 33 – World Health Organisation (WHO)
  • Page 34 – Emory University – ADRC Research Centre
  • Page 34 – Wikipedia
  • Page 34Agency for Healthcare Research and Quality, US Dept of Health
  • Page 35 –
  • Page 35 – Functional Medicine Coaching Academy (training for Dr Bredesen’s protocol)
  • Page 38 – SharpAgainNaturally
  • Page 39 – Healing Advocates


(Analysis, Conclusions and summary – to come)

Dr Dale Bredeson’s book: End of Alzheimer’s :

Dr. Dale Bredesen has created the ReCODE protocol that involves multiple strategies to address specific health issues that contribute to Alzheimer’s Disease (AD). The results of each strategy are measured by using blood tests, cognitive evaluations, and other markers of overall health improvements. Actions are tweaked over time to aim for optimal lab and evaluation results. His analogy is to think of AD as a leaky roof – there are as many as 36 leaks in the AD roof that need to be addressed to stop the problem. Not every patient will have the same leaks, and the protocol is customized based on the patient’s genetics, current health, and lifestyle.

In 2014, his first published paper on the protocol, Reversal of Cognitive Decline, highlighted 10 case studies. Of those 10 people, nine showed enough improvement to return to normal life activities. Several hundred people with cognitive impairment have since followed the protocol, and most have seen a reversal of cognitive impairment. He published results of reversing various levels of cognitive decline in Reversal of Cognitive Decline: 100 patients, published October 2018. His book The End of Alzheimer’s, published August 2017 discusses his protocol and explains many of the mechanisms of Alzheimer’s.

Bredesen’s protocol has not been tested as a preventative, however in a May 2019 podcast interview, Dr Bredesen did say that he’s never had someone at risk come in for prevention and develop even mild cognitive impairment. Research has shown that amyloid-? is deposited in E4 carriers as early as their thirties, so addressing components prior to experiencing cognitive impairment symptoms will likely lead to better health and cognition in aging. Members on the APOE4.Info forum who follow the protocol report improvements not only in health but also in cognition, even if they do not have an SCI or MCI diagnosis.

Although Bredesen does not see private patients, he has made his protocol available to those seeking doctor assistance through AHNP: Precision Health. MPI Cognition, his previous affiliation, was acquired by AHNP and his prior affiliation with Muses Labs has ended.

Dr Brederson has been researching Alzheimers with a highly qualified team for 25 years. Their view is that what is measured, in particular plaques and tangles (all explained in the book) are only the indirect cause of brain cells being killed deliberately.  The real cause, he explains, is that the brain has a natural defence mechanism that tries to stop the plaques and tangles forming and, if these build up too much, it goes haywire and starts killing too many brain cells.  The trick is to stop the mechanisms that cause the plaque and tangle growth. They have identified 36 so far (see below), and expect just a few more to be found.  These come in categories of inflammatory, toxic and nutrients.  Their programme is to identify which are the major causes for each individual – it varies it seems – and tackle each one starting with the most prominent.  Their program is called ReCODE, and they are training numerous nurses and doctors to apply it.  The reason ReCODE hasn’t made the main stream is they are not allowed to carry out formal test approval programs, as required for all approved medical drugs.  Big Pharma only want to sell huge numbers of pills.  Problem is, it isn’t a matter of one super pill as each person’s needs vary as which of the 36+ are the major causes, so testing just one would be a waste of time and only appear to prove the treatment doesn’t work.  Ie stop the plaques and tangles forming and the brain’s defence mechanism reckons all is now well, stops killing cells and shuts down until needed.  But the official approval mechanism only allows one factor at a time to be tested, so the approval mechanism for multiple factors has not been approved.  They have had many successes when doctors who knew of this program sent their patients to Dr Bredesen – with amazing full recoveries. The list below links to summaries of why each strategy is important, what you can do, and a selection of research references.

The remainder of the working paper can be viewed at the link above.


About Peter Senior

I'm a very experienced and pragmatic management consultant. I've reviewed and led the restructuring of many organisations - large and small corporations and Government Departments, much of the time as President of the New Zealand Institute of Management Consultants. Before that I was General Manager of a major NZ newspaper; earlier, an analyst for IBM UK. I gained an honours degree in engineering at London University, and studied management at Cambridge University. This wide range of experience has left me frustrated: I continue to see too many examples of really bad management. Sometimes small easily fixed issues; sometimes fundamental faults; and sometimes really tricky problems. Mostly these issues can be fixed using a mixture of common sense, 'management 101' and applying lessons from years of management experience. Unfortunately, all too often, politics, bureaucracy and daft government regulations get in the way; internal factors such as poor culture and out-of-date strategies are often evident. So what's gone wrong, and why, and most importantly, how to fix 'it'? I hope there are like-minded people 'out there' who will share their thoughts enabling 'us' to improve some significant management failures that affect the general public. If you just accept bad management, you don't have the right to complain! If you'd like to share thoughts on any aspects of management, send me an email to . My latest project has the interim title 'You’ve been conned. Much of what you were taught and read is largely irrelevant, misleading or plain wrong – this is the REAL story of life: past, present and our possible future.' The working paper so far comprises 105 pages, many listing references and interim conclusions. The main problem is finding sufficient credible evidence, and realising the more Iearn, the more I realise I don't know!
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